The individual label is the same nominal size: 2-5/8″ × 1″, 30 per sheet. The sheet-level geometry is not identical. Office Depot’s 30-up address layout sits in its own Layout Family (part of the value-brand cluster, LF-0045) separate from Avery 5160 (LF-0001), with a margin drift of roughly 0.06″. The Avery template will not print reliably on the Office Depot sheet.
This is the most searched comparison in office labeling, and the honest answer is more nuanced than "yes they’re the same" or "no they’re not". They are the same where it is cheap to be the same (the die that cuts the label) and different where it quietly matters (where the labels sit on the page).
The parallel-layout problem
Office Depot, Staples, Amazon Basics, and SheetLabels all ship a 30-up address sheet that parallels Avery 5160 without matching it. We grouped them into a value-brand Layout Family precisely because they resemble each other more than they resemble Avery. If you standardize on any one of them, use its template, not Avery’s.
Bottom line
- Buying Avery? Use the Avery 5160 template (LF-0001).
- Buying Office Depot, Staples, or Amazon Basics? Use the value-brand 30-up template (LF-0045).
- Never mix. The 0.06″ drift compounds down the page.